Senior Scientist Downstream Processing ()



Our client is a young private biotechnology company focused on creating technology to develop new healthcare products. They develop enzyme replacement therapies for lysosomal storage diseases as well as improved antibodies, using a glyco-engineered yeast production host and proprietary, purpose-built development tools.

The research group in Ghent consists of 35 people working in the field of yeast protein expression systems. The downstream processing team  holds 4 team members.


This position is for a full-time Senior Scientist Downstream Processing, who is able to overlook protein purification manufacturing processes in a multiple product pilot facility.

We are looking for a highly motivated senior scientist, who is co-responsible for the purification protocols and can adequately report the results to the Head of CMC.

The following tasks are common in this line of work:

  • Responsible for  technology transfer of downstream  processes to the CMO
  • Responsible from tox to clinical supply
  • Review of production documentation in close collaboration with the CMO
  • (Planning and performing small-scale lab trials to investigate novel purification routes)
  • (Scaling-up of research protocols to be applicable in large scale GMP manufacturing)
  • Experience with large scale column chromatography, tangential flow filtration,  filtration
  • Responsible for planning (personnel, raw materials,..) and execution of the Downstream process at the
  • Key team member for process validation
  • Work closely with fermentation team and quality team to ensure that the purification protocols and processes are compliant and ready for tech transfer to CMO
  • Responsible for tech transfer and follow-up at CMO site where large scale production will be executed


  • Master or PhD in Life Sciences, Biochemical engineering or Biological sciences
  • Min. 8 years of relevant large scale protein purification experience, in a GMP environment
  • Good knowledge of GMP
  • Good problem-solving skills, team player, driven and creative
  • Accurate , pro-active and Strong attention to detail
  • result-oriented, able to work independently
  • Developed communication skills
  • Eligible to live and work in Belgium
  • Willingness to travel in Europe (+30%)
  • A competitive salary package and benefits
  • A dynamic and enthusiastic work environment with project, process and people responsabilities in an innovative company





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